LIPOSOMAL PRODUCTS IN 2019
When we launched Lipolife® Gold Liposomal Vitamin C in 2009, there were very few sole manufacturers of commercial liposomal products globally and none in the EU or UK.
Now, as we enter 2019, there are many more liposomal products on the market and a lot of these claim that their liposomal product is “the best” on the market.
An example of just some of the marketing claims used to promote liposomal products currently on the market
“30 times higher efficiency and better absorption than regular vitamin capsules”
“This patented process allows [us] to achieve 100% liposomal encapsulation with a liposome width of 100nm.”
“Scientifically proven to deliver over 8 times the absorption of regular vitamin tablets.”
“There is no better way to orally supplement vitamin C. Guaranteed!”
“over 90% of [our] Liposomal Vitamin C is absorbed”
"slow release, vegetarian Liposomal Vitamin C 500 mg capsules […] for maximum bioavailability. “
“High potency, superior absorption.”
“revolutionary liposomal technology to ensure the maximum possible absorption by your body.”
“98% ABSORPTION. The most bioavailable vitamin C on the market.”
Competition within a marketplace is healthy; it motivates current and new manufacturers to ensure the product they are producing is top quality and at an affordable price for the consumer.
Unfortunately however, with the food supplement industry largely unregulated, just because a product is labelled as liposomal this doesn’t guarantee the contents, so how can you find out if what you’re buying is a true and ultimately effective liposomal?
The marketing claims alone for such products are littered with misinformation, pseudo-scientific jargon and sweeping “guarantees” of absorption but do any of the brands have proof, detailed clinical data and analyses of their products?
In addition to our recent clinical study and through an independent UK laboratory, we studied the contents of a Lipolife® Gold Vitamin C sachet alongside two other branded liposomal Vitamin C sachets, by inspecting the contents under a microscope.
An Optical Comparison of Commercial Liposomal Vitamin C Formulations Using TEM
To determine the presence of nanoparticles and observe any explicit optical differences in commercial formulations of liposomal vitamin C from three different brands; Lipolife® and two unnamed commercially available liposomal Vitamin C sachets.
Specimens sent for analysis were commercial liposomal Vitamin C suspensions/gels.
All specimens were analysed via Transmission Electron Microscopy (TEM) and were prepared using a negative staining method. TEM analysis was conducted at the TEM suite at the Open University (The Open University, UK).
TEM images are presented side by side and are in size proportion to one another, relative to their corresponding scales.
Figures 1, 2 and 3 show side by side comparisons of Brand A, Brand B and Lipolife Gold liposomal Vitamin C formulations.
Images from Figures 1 (Brand A), 2 (Brand B) and 3 (Lipolife®) all show particles taken from different liposomal Vitamin C products with a scale bar of 500nm.
Figures 1 and 3 presents images from specimens with the most highly concentrated nanosized particles.
The image from Figure 1 shows largely irregular shaped particles most of which appear to be below the 200nm size range.
The image in Figure 2 shows the presence of nanosized particles, however, this specimen has a low concentration of nanoparticles with only two particles clearly visible, approximately in the range of 150-200nm.
The image from Figure 3 shows nanosized particles with smooth edges and spherical structures, most of which appear to be below 150nm. Particles also appear largely uniform in shape and size.
Aggregation and potential fusion of particles can be seen in Figures 1 and 3 which is consistent with liposomal membrane fusion.
TEM images were of good quality, contrasting clearly on a stained background.
Although not all images show symmetrical liposomes with spherical shapes, following the examination of all formulations, Lipolife displayed symmetric nanoparticles with clearly defined, smooth and circular edges whose shape and behaviour are most consistent with those of liposomes.
Furthermore, the particles in Lipolife® were overall the smallest in all specimens analysed with the concentration of nanoparticles in Lipolife® and Brand A being visibly greater than was observed in Brand B.
The particles present in Brand A and Brand B, due to their visible amorphous characteristics, makes for the hypothesis of positive liposome presence difficult.
© Lipolife 2019