Exploring the Benefits of Levagen+
A Revolutionary Wellness Ingredient
In the realm of health and wellness, constant innovation drives the development of new and effective supplements. One such groundbreaking ingredient making waves in the industry is Levagen+. This cutting-edge compound has gained attention for its potential to promote overall well-being and address various health concerns.
Understanding Levagen+
Levagen+ is a patented form of palmitoylethanolamide (PEA), a fatty acid naturally produced in the body. PEA is renowned for its anti-inflammatory and analgesic properties, which contribute to its potential therapeutic effects. Levagen+ is a highly bioavailable and stable form of PEA, making it an attractive option for those seeking natural solutions to enhance their well-being.
Anti-Inflammatory Properties
One of the key features of Levagen+ is its anti-inflammatory properties. Inflammation is a natural response by the body to injury or infection, but chronic inflammation can lead to various health issues. Levagen+ has been studied for its ability to modulate the inflammatory response, potentially providing relief for conditions associated with inflammation.
Pain Management
Levagen+ has demonstrated promising results in the realm of pain management. Its analgesic effects make it a potential candidate for addressing chronic pain conditions. Studies have explored its use in conditions such as neuropathic pain and osteoarthritis, showing encouraging outcomes.
Neuroprotective Effects
Beyond its anti-inflammatory and analgesic properties, Levagen+ has also been investigated for its neuroprotective effects. Some studies suggest that it may have a role in supporting nerve health and protecting against neurodegenerative conditions. This opens up new possibilities for incorporating Levagen+ into formulations designed to support cognitive function.
Immune System Support
The immune system plays a crucial role in maintaining overall health. Levagen+ has been studied for its immunomodulatory effects, indicating its potential to support a balanced immune response. This could be particularly beneficial for individuals looking to enhance their immune system function.
Applications and Future Research
As research on this innovative compound continues, we can expect to see a growing body of evidence supporting its efficacy in different applications.
Levagen+ represents a promising development in the world of health and wellness. Its multifaceted benefits, ranging from anti-inflammatory and analgesic effects to potential neuroprotective and immune system support, make it an intriguing ingredient for those seeking natural alternatives.
With ongoing research, Levagen+ may emerge as a key player in promoting a holistic approach to health and vitality.
Supporting Joint Health with Levagen®+
Levagen® has been proven to improve symptoms of joint discomfort, stiffness and function dose-dependently over the course of 8 weeks.
Palmitoylethanolamide is both a powerful anti-inflammatory and pain reliever, providing an all-in-one solution for managing discomfort.
Steels, Elizabeth. et al. “A double-blind” randomised placebo controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritis.” Inflammopharmacology 27.3 (2019): 475 – 485
Headache Study
PEA operates through multiple pathways and mechanisms within the body to provide its beneficial effects:
Directly
PEA reduces inflammation locally by binding on to PPAR-a receptors and inhibiting secretion of pro-inflammatory signalling molecules.
PEA enhances the levels and actions of other compounds that are anti-inflammatory and provide pain relief (1, 2). This mechanism is known as the ‘entourage effect’. PEA has a naturally low affinity for CB1 and CB2 receptors and only activates transient receptor potential vanilloid type-1 (TRPV1) channels when at very high concentrations in the body. TRPV1 channels are found on the outside of nerve cells and play a part in pain and temperature regulation (3).
Indirectly
To exert its beneficial effects. PEA can enhance the levels and actions of another endocannabinoid, anandamide, which is often dubbed as the ‘bliss’ molecule or the body’s own natural THC (the compound in cannabis that has psychoactive effects and produces a ‘high’). Anandamide has a profound analgesic response, before the pain signal even arrives at the spinal cord. The mode of action that PEA acts upon is by inhibiting the enzyme that degrades this molecule – Fatty Acid Amide Hydrolaze (FAAH). Anandamide act upon CB1 and CB2 receptors and TRPV1 channels, helping to combat pain and increase relaxation (4, 5, 6).
Joint Pain Study
Change in VAS score from baseline for morning (A) and evening (B) over 2 weeks. * significant difference between groups p < 0.05.
Relax with Levagen
Supplementing with has been found to significantly reduce levels of anxiety and increase quality of life within 14 days. PEA helps improve mood through its ability to influence the endocannabinoid system, which is known to have an influence on mood and sleep.
Enhance Sports Performance with Levagen
Pushing past your limits is necessary when wanting to adapt and beat your competition. Levagen+ helps you push past your threshold by reducing lactic acid build up and decreasing fatigue. Clinical studies have also found Levagen+ to reduce muscle damage and stimulate growth of muscle tissue post-exercise, allowing individuals to reduce recovery time and enhance muscle adaptations.
Mallard, Briskey, Richards, Mills & Rao "The Effect of Orally Dosed Levagen palmitoylethanolamide on Exercise Recovery in Healthy Males - A Double-Blind, Randomized, Placebo-Controlled Study". Nutrients 12.3 (2020):596
Neuropathic Pain Study
BPI-PN (A) Pain Severity scores at baseline, 2, 4, 6 and 8 weeks and (B) Pain interference score at baseline, 4 and 8 weeks scores for the active treatment group and the placebo group.
Migraine Study
(A) Total VAS score over the first 4 h and (B) change in VAS score over the first 4 h. a= significant difference from the baseline in the Levagen+ group (p < 0.05); b = significant difference from the baseline in the placebo group (p < 0.05); *=significant difference between groups (p < 0.05).
Levagen+ was clinically researched to significantly reduce VAS scores and resolved migraines classified as moderate when compared to placebo.
Cognitive Function Study
In a brand new study, Levagen®+ efficacy was studied at 700mg or a matching placebo for 6 weeks in a double armed, cross-over trail.
Levagen®+ supported significant improvement in serum BDNF levels when compared to placebo and helped to improve memory through better first success and fewer errors.
Kim N, Parolin B, Renshaw D, Deb SK, Zariwala MG. Formulated Palmitoylethanolamide Supplementation Improves Parameters of Cognitive Function and BDNF Levels in Young, Healthy Adults: A Randomised Cross-Over Trial. Nutrients. 2024.
Skin Health Study
The recently published topical study showed the efficacy of Levagen®+ in a topical formulation applied twice daily for 4 weeks.
Levagen®+ supported a significant reduction in skin dryness, skin redness, and reduced a total POEM score compared to a comparator cream.
Rao A, Moussa AA, Erickson J, Briskey D. Efficacy of Topical Palmitoylethanolamide (Levagen+) for the Management of Eczema Symptoms: A Double-Blind, Comparator-Controlled, Randomized Clinical Trial. Skin Pharmacol Physiol. 2023
Skeletal Muscle Hypertrophy Study
In the recently published study, the efficacy of Levagen®+ was evaluated for improvement in skeletal muscle hypertrophy, physical strength, and physical power.
The study demonstrated that 300mg Levagen®+ taken daily during an 8 week strength training protocol does not interfere with strength training and can even contribute to increased lower body power.
Huschtscha, Z., Silver, J., Gerhardy, M., Urwin, C. S., Kenney, N., Le, V. H., Fyfe, J. J., Feros, S. A., Betik, A. C., Shaw, C. S., Main, L. C., Abbott, G., Tan, S. Y., May, A., Smith, C. M., Kuriel, V., Barnard, J., & Hamilton, D. L. (2024). The Effect of Palmitoylethanolamide (PEA) on Skeletal Muscle Hypertrophy, Strength, and Power in Response to Resistance Training in Healthy Active Adults: A Double-Blind Randomized Control Trial. Sports medicine - open, 10(1), 66.
