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Liposomal PEA (Palmitoylethanolamide)

Name: Liposomal PEA (Palmitoylethanolamide)
Brand: Lipolife
SKU: LLP2
Price: 39.99 GBP
Availability: OutOfStock

SPOTLIGHT ACTIVE:

SUPPLEMENT FORM: Liquid

FLAVOUR: Unflavoured

£39.99

PEA (Palmitoylethanolamide) is a fatty acid amide produced by the body to help regulate inflammation and manage pain. But when taken in traditional form, its absorption can be limited.

That’s why lipolife® uses liposomal technology, a delivery system where PEA is encapsulated in microscopic lipid spheres called liposomes. These liposomes protect PEA from being broken down too early in the digestive system, allowing significantly more of the active ingredient to reach your cells.

Authenticity

lipolife® use premium active ingredients, with verifiable clinical data where available.

View efficacy of palmitoylethanolamide supplementation

Nutritional Information

Nutrient	Amount per Serving (5ml)	% RI
Palmitoylethanolamide	150mg	*

%RI = % Reference Intake
* = %RI not established

Ingredients

Ultra-Pure Water, Phospholipids (non GMO Sunflower, Lipoid®), Palmitoylethanolamide (Levagen®+), Glycerol, Acacia Gum (stabiliser), Mixed Tocopherols (antioxidant), Citric Acid (acidity regulator), Calcium Chloride (stabiliser), Potassium Sorbate (preservative).

Directions

Tastes best chilled. Shake before use, take 5ml per day or as professionally directed.

Product Details

Palmitoylethanolamide (PEA) is a naturally occurring fatty compound made in the body and found in foods like egg yolks and peanuts. It plays a vital role in reducing pain, calming inflammation and supporting nerve health. PEA works by interacting with receptors in the body that help regulate inflammation and protect nerve cells, without the side effects commonly associated with synthetic pain relief options.

Backed by decades of clinical research, PEA has been shown to be effective for:

Chronic pain conditions
Neuropathic (nerve) pain
Inflammation related to autoimmune and musculoskeletal issues
Recovery after injury or surgery

But while PEA is powerful, it’s also delicate. Its absorption in the body is naturally low, which limits its therapeutic potential in standard supplement form.

That’s where lipolife® makes the difference. Using advanced liposomal technology, we encapsulate PEA in microscopic lipid spheres called liposomes. These liposomes shield the PEA through the digestive tract and deliver it directly into the bloodstream, markedly increasing its absorption and effectiveness.

The result? A smarter, faster, more targeted way to support:

Pain relief
Anti-inflammatory response
Nerve regeneration and immune balance

lipolife® liposomal PEA is ideal for anyone seeking natural, non-toxic pain support backed by cutting-edge science and pharmaceutical-grade delivery.

Safety Warnings

Do not exceed recommended daily dose. Food supplements should not be used as a substitute for a healthy lifestyle or balanced diet. Always consult with your healthcare professional before starting any supplement.

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It's helped with my severe back pain

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what’s in your bottle?

lipolife® liposomal palmitoylethanolamide

A recent double-blind, placebo-controlled clinical trial evaluated the effectiveness of Levagen+, a bioavailable form of Palmitoylethanolamide, in managing migraine pain. The study involved 80 healthy adults aged 19 to 65, each experiencing at least one migraine every two months.

Levagen+ was found to significantly reduce pain scores at 1.5 and 4 hours post-dose compared to placebo with more participants in the Levagen+ group experienced complete migraine resolution within 2 and 8 hours.

It was also found that the need for rescue medications was significantly lower in the Levagen+ group.

Ultra Pure Water

In liposomal supplement manufacturing, ultra-pure water is essential to ensure product stability, safety, and effectiveness. One of the key steps in achieving this high level of water purity is the use of deionised water (DI water).

Deionised water is created by removing the mineral ions (such as calcium, magnesium, sodium, chloride, sulfate and carbonate) that are commonly found in tap or distilled water. This is typically done using ion exchange resins, which attract and trap positively and negatively charged particles (ions). The process involves passing water through a mixed-bed resin or through sequential cation and anion exchange columns, which exchange undesirable ions for hydrogen (H⁺) and hydroxide (OH⁻) ions. These combine to form pure water (H₂O) as the by-product.

While deionisation removes charged particles, it does not eliminate organic contaminants, bacteria, or particulates.

For this reason, SAIFx® Technology used in lipolife® formulations takes it a step further to achieve ultra-pure water by integrating additional purification steps. The resulting ultra-pure water is chemically neutral and microbiologically clean, which is crucial for liposomal formulations. Any impurities, especially ions or microbes, could compromise the integrity of the phospholipid bilayers that form liposomes, affect shelf stability, or introduce contamination into the final product.

Phospholipids

Phospholipids, the core of all lipolife® products, are naturally occurring molecules that form the structural basis of cell membranes. They are essential in nutrient delivery due to their biocompatibility and ability to form liposomes, which can encapsulate active ingredients for targeted delivery.

lipolife® use phospholipids from Lipoid.

Lipoid GmbH is a leading global company specialising in the production of high-purity phospholipids for pharmaceutical, cosmetic and nutritional applications. Lipoid has established itself as a pioneer in developing liposomal and lipid-based drug delivery systems. These systems are critical for enhancing the efficacy and stability of active pharmaceutical ingredients, particularly in formulations such as liposomes, emulsions and lipid nanoparticles.

Levagen®+

Levagen®+ is an advanced, clinically studied form of Palmitoylethanolamide.

To overcome this, Levagen®+ utilises LipiSperse® technology, enhancing its bioavailability by up to 1.8 times compared to standard PEA. In addition, lipolife® employ SAIFx® Technology, wrapping the Levagen®+ in advanced liposomes to further enhance absorption by the body.

Clinical studies have shown that Levagen®+ can reduce joint discomfort, stiffness, and improve function in individuals with mild to moderate osteoarthritis.

For pain relief, Levagen®+ has been found to alleviate various types of pain, including chronic pain and migraines, by reducing inflammation and modulating pain perception pathways.

During clinical studies, various users report improved sleep quality and reduced anxiety when supplementing with Levagen®+, suggesting its potential role in promoting relaxation and better sleep patterns.

There is also emerging research which indicates that Levagen®+ may support cognitive health, including memory and executive function, possibly due to its anti-inflammatory and neuroprotective properties.

Last and by no means least, Levagen®+ has demonstrated the ability to reduce histamine and pro-inflammatory cytokines, indicating potential benefits for conditions like allergic rhinitis (hay fever) and general immune system support.

What does Palmitoylethanolamide do in the body?

Palmitoylethanolamide (PEA) is an endocannabinoid-like lipid mediator with extensively documented anti-inflammatory, analgesic, antimicrobial, immunomodulatory and neuroprotective effects.

Several studies have investigated PEA’s efficacy in managing different types of pain. PEA’s mechanism of action involves targeting receptors involved in pain signalling, providing relief without the side effects associated with many traditional pain medications. A randomised, controlled trial published in The Journal of Pain Research in 2017, examined the use of PEA in patients with chronic pelvic pain. The study found that PEA supplementation led to a significant reduction in pain intensity compared to the control group. Another study published in the Journal of Pain & Relief in 2013 explored the use of PEA in patients with carpal tunnel syndrome, reporting a reduction in pain and improved nerve function.

Emerging research has explored the potential impact of PEA on mood and emotional well-being. Some studies suggest that PEA may have anxiolytic and antidepressant effects, possibly through its influence on the endocannabinoid system and other neurotransmitter systems. However, further research is necessary to establish its efficacy in this regard.

Palmitoylethanolamide is a fascinating compound with a range of potential health benefits, particularly in the realms of inflammation management, pain relief, neuroprotection, and immune system modulation. While research is ongoing, the current body of evidence suggests that PEA could be a valuable addition to the arsenal of natural compounds that support overall health and well-being.

Is PEA better than CBD?

PEA is classified as a "endocannabinoid-like" compound because it interacts with the body's endocannabinoid system, which plays a role in regulating various physiological functions, including pain and inflammation. In this respect, it can be considered as a similar compound to CBD.

While both PEA and CBD interact with the endocannabinoid system, PEA offers a non-psychoactive, legal alternative with a strong safety profile. Unlike CBD, PEA is not subject to the same regulatory restrictions and has been shown to be well-tolerated in clinical studies.

Does PEA really work for pain?

Palmitoylethanolamide (PEA) has been shown to help reduce pain intensity in individuals by down-regulating mast cell activation and modulating glial cell behaviour, two key processes involved in inflammation and chronic pain.

Patients who supplement with PEA often report lower pain levels compared to those who do not. For example, individuals suffering from chronic back pain have experienced significant relief when using PEA.

Research has also highlighted PEA's effectiveness in managing pelvic pain. In one clinical study involving women, daily supplementation with PEA over a six-month period not only reduced pain but also improved symptoms related to sexual function, leading to a notable improvement in overall quality of life.

In addition to its pain-relieving properties, PEA shows promise in neurological recovery. In stroke patients, PEA supplementation has been associated with improvements in cognitive function and brain health outcomes when compared to those who did not receive the compound.

What does PEA do to the brain?

Palmitoylethanolamide (PEA) plays a neuroprotective and anti-inflammatory role in the brain, acting through several mechanisms to support brain health, reduce neuroinflammation, and help manage pain and neurological symptoms.

PEA helps reduce the activation of glial cells (astrocytes and microglia), which are key drivers of inflammation in the brain and nervous system. Overactive glial cells are linked to conditions like chronic pain, stroke, neurodegeneration, and mood disorders. PEA acts as a glial modulator, helping to restore balance and reduce the release of pro-inflammatory cytokines.

Mast cells in the brain contribute to neuroinflammation, particularly in conditions like migraines, multiple sclerosis, and fibromyalgia. PEA inhibits mast cell degranulation, which helps calm neuroimmune responses and reduce hypersensitivity.

VEGAN

All lipolife products are
100% vegan.

GLUTEN FREE

All lipolife product are
100% gluten free

VERIFIABLE SCIENCE

lipolife is the #1 scientifically
proven range of liposomal
supplements

100% UK

lipolife products are
researched, developed and
produced at our UK HQ.

PLANET FRIENDLY

We've only got one planet.
lipolife products are certified
carbon neutral.

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Liposomal PEA (Palmitoylethanolamide)