Liposomal Vitamin B12

In liposomal supplement manufacturing, ultra-pure water is essential to ensure product stability, safety, and effectiveness. One of the key steps in achieving this high level of water purity is the use of deionised water (DI water).

Deionised water is created by removing the mineral ions (such as calcium, magnesium, sodium, chloride, sulfate and carbonate) that are commonly found in tap or distilled water. This is typically done using ion exchange resins, which attract and trap positively and negatively charged particles (ions). The process involves passing water through a mixed-bed resin or through sequential cation and anion exchange columns, which exchange undesirable ions for hydrogen (H⁺) and hydroxide (OH⁻) ions. These combine to form pure water (H₂O) as the by-product.

While deionisation removes charged particles, it does not eliminate organic contaminants, bacteria, or particulates.

For this reason, SAIFx® Technology used in lipolife® formulations takes it a step further to achieve ultra-pure water by integrating additional purification steps. The resulting ultra-pure water is chemically neutral and microbiologically clean, which is crucial for liposomal formulations. Any impurities, especially ions or microbes, could compromise the integrity of the phospholipid bilayers that form liposomes, affect shelf stability, or introduce contamination into the final product.

Phospholipids, the core of all lipolife® products, are naturally occurring molecules that form the structural basis of cell membranes. They are essential in nutrient delivery due to their biocompatibility and ability to form liposomes, which can encapsulate active ingredients for targeted delivery.

lipolife® use phospholipids from Lipoid.

Lipoid GmbH is a leading global company specialising in the production of high-purity phospholipids for pharmaceutical, cosmetic and nutritional applications. Lipoid has established itself as a pioneer in developing liposomal and lipid-based drug delivery systems. These systems are critical for enhancing the efficacy and stability of active pharmaceutical ingredients, particularly in formulations such as liposomes, emulsions and lipid nanoparticles.

The hydroxy form of vitamin B12, known as hydroxocobalamin, is considered particularly beneficial for a wide range of individuals because of its versatility, longer retention time and lower risk of side effects.

The body can convert this form into both methylcobalamin and adenosylcobalamin, the two active coenzyme forms used in the body, giving your system flexibility to utilise the form it needs. Additionally, hydroxocobalamin has a longer half-life in the bloodstream in comparison to cheaper, synthetic forms like cyanocobalamin. This means it stays in your system longer, maintaining steadier B12 levels over time and reducing the need for frequent supplementation.