Liposomal Folate

In liposomal supplement manufacturing, ultra-pure water is essential to ensure product stability, safety, and effectiveness. One of the key steps in achieving this high level of water purity is the use of deionised water (DI water).

Deionised water is created by removing the mineral ions (such as calcium, magnesium, sodium, chloride, sulfate and carbonate) that are commonly found in tap or distilled water. This is typically done using ion exchange resins, which attract and trap positively and negatively charged particles (ions). The process involves passing water through a mixed-bed resin or through sequential cation and anion exchange columns, which exchange undesirable ions for hydrogen (H⁺) and hydroxide (OH⁻) ions. These combine to form pure water (H₂O) as the by-product.

While deionisation removes charged particles, it does not eliminate organic contaminants, bacteria, or particulates.

For this reason, SAIFx® Technology used in lipolife® formulations takes it a step further to achieve ultra-pure water by integrating additional purification steps. The resulting ultra-pure water is chemically neutral and microbiologically clean, which is crucial for liposomal formulations. Any impurities, especially ions or microbes, could compromise the integrity of the phospholipid bilayers that form liposomes, affect shelf stability, or introduce contamination into the final product.

Phospholipids, the core of all lipolife® products, are naturally occurring molecules that form the structural basis of cell membranes. They are essential in nutrient delivery due to their biocompatibility and ability to form liposomes, which can encapsulate active ingredients for targeted delivery.

lipolife® use phospholipids from Lipoid.

Lipoid GmbH is a leading global company specialising in the production of high-purity phospholipids for pharmaceutical, cosmetic and nutritional applications. Lipoid has established itself as a pioneer in developing liposomal and lipid-based drug delivery systems. These systems are critical for enhancing the efficacy and stability of active pharmaceutical ingredients, particularly in formulations such as liposomes, emulsions and lipid nanoparticles.

5-MTHF, also known as methylfolate or L-methylfolate, is the active form of folate that is directly involved in cellular processes. It is the end product of the enzymatic conversion of both folic acid and dietary folate within the body.

5-MTHF is the form of folate that can be directly used by cells and does not require further conversion. This form is believed to have higher bioavailability and effectiveness compared to folic acid because it bypasses the enzymatic steps required for conversion.