Resveratrol and Quercetin are two functional ingredients to which a fat-reducing effect has been attributed in experiments conducted in vivo and in vitro however, their rapid metabolism means that only a tiny fraction of these compounds reach organs and tissue.
Obesity is defined as excess accumulation of body fat, which can result in the development of a whole range of comorbidities. According to the World Health Organisation (WHO), in 2016, 39% of adults were overweight and 13% obese. More concerningly, 41 million children under five are overweight or obese, and 340 million in the case of children and teenagers between the ages of five and nineteen.
Phenolic compounds are antioxidants that occur naturally in plants, which produce them as a defense mechanism in response to stress. Thanks to previous studies, a diet rich in phenolic compounds has been found to maintain an optimum state of health and reduce the occurrence of certain diseases, including cardiovascular diseases, cancer and diabetes. When phenolic compounds have more than one phenolic ring in their structure, these compounds are then known as polyphenols, a more widely known term. Resveratrol and quercetin are currently two of the most studied polyphenols.
The beneficial effects of resveratrol were first described in 1982, when, thanks to an observational study, an inverse relationship was established between moderate red wine consumption and the prevalence of cardiovascular disease. This observation later became known as the “French Paradox.” This polyphenol is found mostly in grapes and the beverages made from them (grape juice and wine), berries and peanuts, among other things, and various biological functions have been attributed to it, including antioxidant, anti-inflammatory, immunomodulating, anti-diabetic and anti-carcinogenic functions. It has also been found to have anti-obesity functions owing to the reduction in body fat through such mechanisms as food intake modulation, modification of nutrient absorption, regulation of the cell cycle of adipocytes, reduction in adipose tissue inflammation, regulation of mitochondrial function, induction of thermogenesis, and modulation of intestinal microbiota.
The Ph.D. thesis by Itziar Eseberri-Barace takes this research a step further, demonstrating that certain metabolites of resveratrol and quercetin molecules, the products that remain following their digestion, remain biologically active and partly contribute to the anti-obesity effect of the compounds.
“The results obtained show that all the metabolites from resveratrol contribute to the same degree as the polyphenol toward inhibiting adipogenesis. Although they are active in mature adipocytes, resveratrol is much more effective. In the case of quercetin, this effect can only be attributed to the sulphated metabolite (quercetin-3-0-sulphate) in mature adipocytes, since none of the quercetin metabolites turned out to be as effective as or more effective than the polyphenol on its own in inhibiting adipogenesis,” explained Eseberri-Barace. “It can therefore be concluded that the metabolism of these two compounds can signify a limitation only in the case of mature adipocytes treated with resveratrol and pre-adipocytes in differentiation treated with quercetin.”
Note that apart from their low bioavailability, phenolic compounds only occur in small quantities in foodstuffs, because after they have been digested, they undergo extensive metabolisation, with the result that the amount that reaches organs and tissue is relatively low.
Liposomal encapsulation ultimately leads to higher absorption and more crucially, higher systemic bioavailability of Resveratrol and Quercetin.
Lipolife offers both Resveratrol and Quercetin in a Liposomal formula and hope to further advance the research of their role in potential inhibition of adipogenesis in the coming years.
C3 Complex by Sabinsa, used in Lipolife® Curcumin, was used in a newly published study on Non-Alcoholic Fatty Liver Disease (NAFLD), the most common chronic liver condition for which no approved pharmaceutical treatments currently exist.
NAFLD is a spectrum of disorders ranging from steatosis, non-alcoholic steatohepatitis (NASH), fibrosis, and cirrhosis of the liver.
It is also commonly associated with metabolic syndrome and cardiovascular diseases. It’s estimated up to 1 in every 3 people in the UK has early stages of NAFLD, where there are small amounts of fat in their liver.
The peer-reviewed paper published in the Journal of Cellular Biochemistry, 2019; 120: 15989-reports on the efficacy of C3 Complex combined with Sabinsa’s bioavailability enhancer BioPerine® on NAFLD subjects in a randomised controlled parallel-group clinical trial.
The decrease in the severity of NAFLD in the subjects was gauged by hepatic sonography, and significant improvement was observed in several elevated liver function parameters such as ALT, ASP, and ALP in NAFLD subjects treated with the C3 Complex and BioPerine combination. NAFLD severity was reduced in a statistically significant way in the treatment group compared to the placebo group. No adverse effect on the hematological parameters were found, showing the safety of the ingredients.
Taking this powerhouse compound in a liposomal formula with proven increased absorption could be considered as majorly beneficial to those concerned by their own liver health.
The study may be accessed here: 15996 https://doi.org/10.1002/jcb.28877
We were delighted to receive the following review of Lipolife Multi-C from Natural Health Magazine in their feature “This month we’ve been…”
“The number of vitamin supplements available, combined with the confusing labels and our lack of expert nutritional knowledge, can turn the simple task of bettering our health into a seemingly impossible task. So, when I was asked to try Lipolife’s Multi-C Liposomal Multi-Vitamin I could have not been happier to give it a go. I decided to take the pineapple flavoured mixture on its own every morning – ensuring I was ready for the day ahead.
I was delighted to find this multi-vitamin can help boost the immune system, and I believe it did. Usually I am the first to suffer yet, by consuming a teaspoon everyday I haven’t even had a runny nose. It’s important to remember that you consult with your doctor before taking vitamin supplements for the first time.”
Make sure you help support your immune system this Winter by adding Multi-C to your daily routine.
For more details on where to buy online or to find a stockist hear you, please see here
As a parent, as soon as you hear “back to school” your mind instantly goes straight to the typical checklist;
Uniform? Tick! Shoes? Tick! Stationery? Tick!
But have you considered their immunity?
There’s no hiding from the fact that we’re heading towards winter and with that comes the infamous “cold and flu season.”
You can bet that those dreaded germs will spread quicker than you can say ‘Achoo’ as soon as your child enters the classroom… there’s always something going around!
CHOOSE LIPOLIFE® IMMU-POW VITAMINS C & D3
…send them back to school healthy, protected and strong.
Lipolife® formulations, deliver nutrients directly to the cells, ensuring much higher absorption.
For more information about getting #backtoschool with LIPOLIFE® IMMU-POW, CLICK HERE!
Lipolife collaborates with doctors and leading academics in the field of nanotechnology to remain at the forefront of the food supplement industry. Our liposomal supplements are clinically proven, laboratory tested, and microscopically confirmed.
We often commission small, independent studies on our supplements and publish the results across our platforms; by conducting further research, it shows an insight into the effectiveness of our products and ensures consumers they’re investing in a class-leading, effective supplement.
We’re looking for vegans and vegetarians in the UK, who aren’t currently supplementing with B12, to take part in our study.
All it will take is three simple steps;
- Participants will receive a simple and easy-to-do, at-home, finger prick blood test that measures active B12 in the blood. The test will be sent by Thriva; Lipolife will cover the cost (£40).
- Participants with low B12 levels results will then receive Lipolife Hydroxy B12 liposomal supplement and further instructions on dosage.
- B12 blood tests will be sent out to again at the completion of the prescribed course.
Unfortunately, those who are already supplementing with B12, or have consumed meat in the last three months are excluded from the study*.
(*If you are not a vegan or vegetarian but believe you may suffer from a B12 deficiency you may qualify so please get in touch.)
** Please note, we have fulfilled our quota for female participants and are now only looking for male volunteers.
To register your interest or for more information, please email the Principal Investigator and Lipolife® Scientific Advisor, Tony Tiller firstname.lastname@example.org
As a result of a small study we conducted, we have data which shows just 4 weeks of supplementation with Lipolife Liposomal D3 increased blood levels of Vitamin D to 210% from baseline.
However, don’t think just because it’s the Summer you don’t need to worry about your Vitamin D levels!
Do you work in an office? Do you do night-shifts? Maybe you cover up your skin? Perhaps your skin naturally glows, is more pigmented and filters some of the useable UVB? Perhaps you have very fair skin and burn easily or pile on the sunscreen the moment there is a ray of potentially harmful sunshine?
All of these are genuine reasons taken from research as risk factors for poor Vitamin D status, even in the height of summer.
Get your D3, make it liposomal and make it Lipolife.
Contact us for more information on volunteering for future studies with us via email@example.com.
Full study available here.
The rules surrounding health claims for food supplements are very strict; only permitted phrases can be used when looking at the potential health benefits of the nutrient.
Reputable companies will follow these guidelines and only give you the information as sanctioned by the relevant regulatory authority.
When it comes to Vitamin C, there are several approved health claims,
In the media, there are less restrictions and the scientific discoveries researching the power of vitamins are regularly featured in the press and on television.
Last month, This Morning’s Dr Chris talked with Eamonn and Ruth about Vitamin C and a recent study using the nutrient in the treatment of blood cancer.
Unfortunately with the food supplement industry largely unregulated, just because a product is labelled as liposomal this doesn’t guarantee the contents, so how can you find out if what you’re buying is a true and ultimately effective liposomal?
Take a look at the two images below, two different sachets of liposomal vitamin c under the microscope.
Two sachets, two brands, one big (small) difference.
Read more by clicking the microscope.